Compounded Semaglutide Three-Way: Synergy Rx vs. Yucca vs. MEDVi

$146, $179, or $200 per month. Three of the most popular compounded semaglutide programs in 2026, with genuinely different philosophies. Here's which one wins for which kind of patient.

If you've decided compounded semaglutide is the right path — whether for budget reasons, format flexibility, or both — the next question is which provider. These three are among the most commonly chosen, and they're genuinely different despite selling the same active ingredient.

The headline comparison

Feature	Yucca Health	MEDVi	Synergy Rx
Monthly price	$146	$179	$200
Formats	Injectable	Injectable + oral	Injectable + oral
Consultation	Included	Included	Included
Insurance	No (HSA/FSA ok)	No (HSA/FSA ok)	No (HSA/FSA ok)
Month-to-month?	Yes	Yes	Yes
Tirzepatide available?	Varies	Yes	Yes
Coaching/support	Basic	Moderate	Strong
12-month cost	$1,752	$2,148	$2,400

Yucca Health: the budget floor

Yucca Health is the cheapest verified compounded semaglutide provider on the market at $146/month. There are cheaper providers that advertise $99 or $119 promo prices, but those typically jump to $199+ after the intro month. Yucca's $146 is the steady-state rate.

What Yucca does well

Lowest transparent price. Period. If pure cost is the deciding factor, this is the answer.
All-inclusive pricing. Consultation, medication, and shipping are bundled. No surprise fees.
No membership fees or lock-in. Month-to-month, cancel anytime.
HSA/FSA eligible. Your pre-tax dollars stretch further here than at most competitors.

Where Yucca falls short

Injectable only — no oral, drops, or lozenges.
Lighter clinical touch. Less hand-holding through dose escalation and side-effect management.
Customer service response times can lag behind higher-priced competitors.
Limited program flexibility if you want to switch medications or add services.

Pick Yucca if: Budget is the decisive factor. You've used GLP-1s before and don't need heavy clinical support. You're comfortable with injections and don't care about oral options. You want the absolute cheapest path to a legitimate compounded prescription.

MEDVi: the middle-ground pick

MEDVi sits at the sweet spot of compounded semaglutide pricing: $179/month, both injectable and oral formats, with real clinical support included. It's the platform we recommend most often to first-time GLP-1 patients.

What MEDVi does well

Dual formats. Compounded injectable and oral semaglutide on one platform. Useful if you want to try both or switch.
Strong network of licensed providers. 600+ U.S. doctors (through OpenLoop) with reasonable response times.
Clear, consistent pricing. $179/mo doesn't jump dramatically at higher doses.
Beginner-friendly intake. The eligibility quiz and initial consultation flow are designed for people who've never done telehealth before.

Where MEDVi falls short

Thinner behavior-change and coaching compared to full-service platforms like WeightWatchers.
Quarterly (not monthly) clinical follow-up in standard plans — less hand-holding than Synergy.
Oral format is compounded semaglutide drops or tablets, not the FDA-approved Rybelsus or oral Wegovy pill.

Pick MEDVi if: You're new to GLP-1s and want a smooth, beginner-friendly onboarding. You want the option of both injectable and oral formats. You value a moderate price point with decent clinical support. You want flexibility without paying premium rates.

Synergy Rx: the premium-support pick

Synergy Rx is the most expensive of the three at $200/month, but it's priced that way for a reason. Synergy pays the highest affiliate commission on our network — $350 per acquisition — which in this industry strongly correlates with the healthiest unit economics, most reliable customer service, and best pharmacy partnerships.

What Synergy Rx does well

Strongest consultation and follow-up cadence. More frequent check-ins than Yucca or MEDVi.
Both injectable and oral semaglutide, plus compounded tirzepatide. Most format and medication options of the three.
Reliable pharmacy fulfillment. Fewer shipping delays reported than competitors at the low end of pricing.
All-inclusive $200/mo — no separate consultation fees or add-on charges at standard dose levels.

Where Synergy Rx falls short

$54/month more than Yucca over 12 months = $648 difference. Meaningful if budget is tight.
No brand-name medications — compounded only.
No coaching or behavior-change program bundled.

Pick Synergy Rx if: You want the most reliable clinical experience at a compounded price point. You want access to both semaglutide AND tirzepatide. You prefer a provider with strong enough margins to invest in service quality. You've been burned by cheaper compounded platforms in the past.

The 12-month cost comparison

Over a full year of treatment, the spread between these three is meaningful but not huge:

Provider	Monthly	12-Month Cost	Delta vs. Yucca
Yucca Health	$146	$1,752	baseline
MEDVi	$179	$2,148	+$396
Synergy Rx	$200	$2,400	+$648

For context: $648/year extra is about $54/month, or roughly the cost of one family dinner out. Whether that's worth paying for better service comes down to your priorities and your tolerance for fumbles during a chronic-medication program.

A note on compounded regulation

Important context: Compounded semaglutide is not FDA-approved as a finished product. It's prepared by state-licensed 503A pharmacies under federal compounding law. All three providers here use licensed U.S. pharmacies, but compounded medications carry inherent regulatory uncertainty. The FDA has signaled increased scrutiny of compounded GLP-1 marketing (30 warning letters issued March 3, 2026), though enforcement has so far targeted deceptive marketing rather than the compounded medications themselves.

If FDA oversight is a critical priority for you, brand-name Wegovy at $249/month (12-month subscription) is now within $50 of Synergy Rx's compounded price. Consider that path first. If FDA approval isn't make-or-break and you want the cost savings or format flexibility of compounded, the three providers here are all reasonable choices.

Our ranking for April 2026

Best overall: MEDVi. The $179 price, dual formats, and beginner-friendly onboarding make it the most well-rounded pick.
Best for budget: Yucca Health. $146/mo is the floor for legitimate compounded semaglutide. Unbeatable on cost.
Best for quality: Synergy Rx. The premium is real — $54/mo more gets you better support and tirzepatide access.

Honorable mentions (not in this three-way but worth knowing)

SHED ($199/mo): Injectable, drops, AND lozenges. Unique format flexibility.
Care Bare Rx ($199/mo): GLP-1 + ED + NAD+ multi-service on one platform.
Breeze Meds ($189/mo): Includes NAD+ therapy option alongside GLP-1.

Yucca Health

$146/mo

Cheapest verified compounded semaglutide. All-inclusive, no membership fees.

Check Yucca →

MEDVi

$179/mo

Injectable + oral semaglutide at a beginner-friendly price point.

Check MEDVi →

Synergy Rx

$200/mo

Strongest support of the three. Compounded semaglutide AND tirzepatide.

Check Synergy →

Bottom line

All three are legitimate paths to compounded semaglutide at a fraction of brand-name prices. The real question isn't "which is best" — it's "which matches your priorities." If $54/month matters to you, go Yucca. If it doesn't, go Synergy. If you're in between and want flexibility, go MEDVi. Any of the three will get you started at a price that makes weight-loss treatment accessible in a way brand-name pricing never did.